Soluble Endoglin in the Pathogenesis of Preeclampsia: Investigation of Mechanisms and the Development of Therapeutics

Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction

FC Brownfoot, NJ Hannan, P Cannon, V Nguyen, R Hastie, LJ Parry, S Senadheera, L Tuohey, S Tong, TJ Kaitu'u-Lino

2019-03-01

Background: Preeclampsia is a major complication of pregnancy with no medical treatment. It is associated with placental oxidative..

EGFL7 gene expression is regulated by hypoxia in trophoblast and altered in the plasma of patients with early preeclampsia

CL Whitehead, TJ Kaitu'u-Lino, NK Binder, S Beard, N De Alwis, F Brownfoot, S Tong, NJ Hannan

2018-10-01

Introduction: Preeclampsia is a severe complication of pregnancy, and likely arises from abnormal placental development in early p..

Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction

NJ Hannan, S Beard, NK Binder, K Onda, TJ Kaitu'u-Lino, Q Chen, L Tuohey, M De Silva, S Tong

2017-03-01

Introduction Preeclampsia (PE) and fetal growth restriction (FGR) are among the leading causes of perinatal morbidity and mortalit..

Nuclear factor of activated T-cells (NFAT) regulates soluble fms-like tyrosine kinase-1 secretion (sFlt-1) from human placenta

L Ye, A Gratton, NJ Hannan, P Cannon, M Deo, KR Palmer, S Tong, TJ Kaitu'u-Lino, FC Brownfoot

2016-12-01

Introduction Preeclampsia is a serious complication affecting 5–8% of pregnancies. Central to its pathogenesis is placental hypoxi..

Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta

FC Brownfoot, S Tong, NJ Hannan, R Hastie, P Cannon, TJ Kaitu'u-Lino

2016-05-20

Background: Preeclampsia is associated with the placental release of soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endog..

Loss of Akt increases soluble endoglin release from endothelial cells but not placenta

TJ Kaitu'u-Lino, R Hastie, NJ Hannan, F Brownfoot, M De Silva, P Cannon, L Tuohey, S Tong

2016-04-01

Introduction Preeclampsia is a serious pregnancy complication for which there are no medical treatments. Soluble endoglin is an an..

Metformin as a prevention and treatment for preeclampsia: Effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction

FC Brownfoot, R Hastie, NJ Hannan, P Cannon, L Tuohey, LJ Parry, S Senadheera, SE Illanes, TJ Kaitu'U-Lino, S Tong

2016-03-01

Background Preeclampsia is associated with placental ischemia/hypoxia and secretion of soluble fms-like tyrosine kinase 1 and solu..

Heme oxygenase-1 is not decreased in preeclamptic placenta and does not negatively regulate placental soluble fms-like tyrosine kinase-1 or soluble endoglin secretion

S Tong, TJ Kaitu'u-Lino, K Onda, S Beard, R Hastie, NK Binder, C Cluver, L Tuohey, C Whitehead, F Brownfoot, M De Silva, NJ Hannan

2015-11-01

Elevated placental release of the antiangiogenic factors, soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sENG),..

Effects of Pravastatin on Human Placenta, Endothelium, and Women with Severe Preeclampsia

FC Brownfoot, S Tong, NJ Hannan, NK Binder, SP Walker, P Cannon, R Hastie, K Onda, TJ Kaitu'U-Lino

2015-09-14

Preeclampsia is a major pregnancy complication where excess placental release of soluble fms-like tyrosine kinase-1 (sFlt-1) and s..

YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia

FC Brownfoot, S Tong, NJ Hannan, R Hastie, P Cannon, L Tuohey, TJ Kaitu'u-Lino

2015-09-05

Preeclampsia is a serious complication of pregnancy with no medical treatment. It is caused by intermittent placental hypoxia and ..

Transcription factors E2F1 and E2F3 are expressed in placenta but do not regulate MMP14

TJ Kaitu'u-Lino, R Hastie, P Cannon, H Nguyen, S Lee, NJ Hannan, S Tong

2015-08-01

Introduction Preeclampsia is a serious complication of pregnancy for which there are no efficacious medical treatments. Soluble en..

Peptides do not prevent cleavage of endoglin to produce soluble endoglin

R Hastie, S Tong, P Cannon, F Brownfoot, NJ Hannan, T Kaitu'U-Lino

2014-10-01

MMP14 cleaves membrane bound endoglin to produce soluble endoglin (sEng), an anti-angiogenic factor that causes endothelial dysfun..

Galectin-7 acts as an adhesion molecule during implantation and increased expression is associated with miscarriage

EM Menkhorst, T Gamage, C Cuman, TJ Kaitu'U-Lino, S Tong, E Dimitriadis

2014-03-01

Introduction Galectins are expressed at the fetal-maternal interface and have multiple roles including during blastocyst implantat..

Soluble endoglin production is upregulated by oxysterols but not quenched by pravastatin in primary placental and endothelial cells

FC Brownfoot, N Hannan, K Onda, S Tong, T Kaitu'U-Lino

2014-01-01

Introduction Preeclampsia is a serious pregnancy complication. Soluble endoglin (sEng) is released from the placenta and contribut..

MT-MMPs in pre-eclamptic placenta: Relationship to soluble endoglin production

TJ Kaitu'u-Lino, L Tuohey, L Ye, K Palmer, M Skubisz, S Tong

2013-02-01

Introduction: Pre-eclampsia is a serious complication of pregnancy, characterized by severe endothelial dysfunction resulting in h..